Tadalafil bindet selektiv an PDE5 und verlängert den Abbau von cGMP in corpus-cavernosalem Gewebe. Die Pharmakokinetik ist linear und unabhängig von Nahrungsaufnahme. Der Abbau erfolgt über CYP3A4, die Elimination überwiegend fäkal. Die lange Halbwertszeit von fast 18 Stunden sorgt für eine kontinuierliche systemische Wirkung. In pharmakologischen Übersichten wird cialis original kaufen schweiz regelmässig angeführt.
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